한국인 정상안압녹내장 환자에서 안구반응분석기의 진단적 유용성

• 영문명: Diagnostic Availability of Ocular Response Analyzer in Korean Patients with Normal Tension Glaucoma
• 발행기관: 대한안과학회
• 저자명: 조아란 최윤정 류진영 최규룡,Ah Ran Cho, MD, Yun Jeong Choi, MD, Jin Young Rhew, MD, Kyu Ryong Choi, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume56,number1, 86~92쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.01.15

영문 초록

Purpose: To compare the parameters measured with the ocular response analyzer (ORA; Reichert Inc., Depew, NY, USA) between normal control subjects and patients with normal tension glaucoma (NTG) and to investigate clinical usefulness of ORA. Methods: Intraocular pressure (IOP) and central corneal thickness (CCT) were measured using the Goldmann applanation tonometer (GAT) in 100 eyes of 100 normal subjects and 100 eyes of 100 NTG patients. Four types of ORA parameters, corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated IOP (IOPg), and corneal-compensated IOP (IOPcc) were also measured. Results: The mean CH values were 11.2 mm Hg and 10.3 mm Hg and the mean CRF values were 10.8 mm Hg and 9.9 mm Hg in the normal subjects group and the NTG group, respectively. Mean CH and CRF were significantly lower in NTG patients (p < 0.001) and the IOPcc were higher than normal subjects (p = 0.004). IOPg was in agreement with the GAT IOP (ICC = 0.811) and IOPcc was not correlated with CCT. The cut-off value of ‘IOPcc - IOPg’ as the diagnostic standard parameter was -0.05 mm Hg (sensitivity; 76%, specificity; 55%). Conclusions: IOPg measurements were similar to GAT IOP, and other ORA parameters (CH, CRF, IOPcc) were significantly different between normal subjects and NTG patients. Consequently, the difference of IOPcc and IOPg could be a useful parameter in NTG diagnosis. J Korean Ophthalmol Soc 2015;56(1):86-92

키워드

Biomechanical properties, Intraocular pressure, Normal tension glaucoma, Ocular response analyzer