스펙트럼 영역 빛간섭단층촬영으로 측정한 사상판 두께의 연령에 따른 변화

• 영문명: Age-Related Changes in the Thickness of the Lamina Cribrosa Measured by Spectral Domain OCT
• 발행기관: 대한안과학회
• 저자명: 백동원 이주화 김재석,Dong Won Paik, MD, Joo Hwa Lee, MD, Jae Suk Kim, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number8, 1261~1268쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.08.15

영문 초록

Purpose: To measure the lamina cribrosa thickness (LCT) in vivo of healthy people and to determine any association between the LCT and age or sex. Methods: We evaluated 100 eyes of 100 healthy volunteers. Forty eyes were selected and divided into 2 specific age groups (38-49 and 78-89 years) and the differences were assessed with respect to age and sex. Each participant underwent a complete eye examination and the LCT was evaluated with spectral domain optical coherence tomography (OCT) using enhanced depth imaging (EDI) mode. Results: Eighty-seven eyes were considered for the measurement and analysis of the LCT and 13 eyes were excluded because of an unclear image for identifying the LCT. The mean age was 55.0 ± 19.5 years. The mean LCT in healthy volunteers was 231.3 ± 41.6 μm (range, 152.5 - 327.5 μm) and a negative relationship was found between LCT and age (LCT = -1.614 × age + 320.191 μm, 95% CI for slope -1.91 to -1.32, r = 0.572, p < 0.001). Regarding differences related to sex, males had relatively thicker LCT than females, irrespective of age, although not statistically significant (p = 0.623). Conclusions: The present study results showed a decrease in human LCT with increasing age. Therefore, a decreasing LCT with an increasing age could be considered a strong risk factor for the development of glaucoma. In addition, measuring the LCT may help to understand the disease prognosis.

키워드

Age, Glaucoma, Lamina cribrosa thickness, Spectral domain OCT