초기 황반변성 환자에서 들쭉 추출물의 효과

• 영문명: The Efficacy of Vaccinium Uliginosum for Early Age-Related Macula Degeneration
• 발행기관: 대한안과학회
• 저자명: 길현경 송유미 전고이,Hyun Kyung Kil, MD, You Mi Song, MD, KoI Chun, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number8, 1255~1260쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.08.15

영문 초록

Purpose: To evaluate the effect of Bog Bilberry (Vaccinium uliginosum) extract in eyes with early age-related macular degeneration (AMD). Methods: Forty- four eyes of forty four patients with early AMD were included in this randomized, double-blinded, and placebo- controlled study. All participants were randomly assigned to either the placebo group (n = 24), or the bog bilberry extract group (n = 20). Before drug administration, an ophthalmic examination which included slit lamp microscopy, best corrected visual acuity, and intraocular pressure was performed, and repeated 1and 3 months after treatment. Objective scatter index, glare and tear film break-up time were checked by Optical Quality Analysis System (OQAS, Visiometrics, Spain) and drusen volume, central macular thickness, and RPE and IS/OS junction thickness were investigated with spectral-domain optical coherence tomography (Spectralis, Heidelberg, Germany). Results: In the bog bilberry extract group, RPE and IS/OS junction thickness was significantly increased compared to the placebo group after 3 months of drug administration. Conclusions: Bog Bilberry extract may play a favorable role in preventing the atrophic change of RPE and IS/OS junction layer and the progression of early macular degeneration.

키워드

Age-related macular degeneration, Bog bilberry, IS/OS junction, Optical coherence tomography