트리암시놀론이 배양된 사람 섬유주세포에 미치는 영향

• 영문명: Effects of Triamcinolone Acetonide in Cultured Trabecular Meshwork Cells
• 발행기관: 대한안과학회
• 저자명: 류시일 장우석 김재우 김시동,Si Il Ryu, M.D., Woo Seok Chang, M.D., Jae Woo Kim, M.D., Si Dong Kim, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume47,number4, 655~660쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.04.30

영문 초록

Purpose: To investigate the effect of triamcinolone acetonide (TA) on the survival, nitric oxide (NO) production, and migration of cultured human trabecular meshwork (TM) cells. Methods: After exposure to TA, indomethacin, and dexamethasone for 2 days, the survival and nitrite production of the primarily cultured human TM cells were assessed with MTT and Griess assays respectively. The effect of co-exposure to the NO donor, sodium nitroprusside, was also assessed. A migration assay was done to evaluate the effect of TA on the activity of TM cells. Results: Cellular survival increased after exposure to TA at low concentration but decreased at high concentration. TA decreased the production of NO significantly (p<0.05). Exposure to indomethacin and dexamethasone revealed similar results. TA reversibly inhibited the migration of TM cells. Conclusions: TA decreases the production of NO and inhibits the migration of TM cells. TA at high concentration decreases cellular survival accompanied with decreased NO production. These effects of TA on TM cells may result in the elevation of intraocular pressure.

키워드

Migration, Nitric oxide, Trabecular meshwork cells, Triamcinolone acetonide