각막질환에 따른 각막이식술후 각막내피세포의 변화

• 영문명: Evaluation of Donor Corneal Endothelium after Keratoplasty
• 발행기관: 대한안과학회
• 저자명: 길소연 박찬기 한태원,So Yeon Gil, M.D., Chan Kee Park, M.D., Tae Won Hahn, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume47,number4, 519~524쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.04.30

영문 초록

Purpose: To investigate the difference in donor corneal cell changes after penetrating keratoplasty in various corneal diseases. Methods: Subjects included 36 eyes from 35 people with at least 6 months of follow-up who had undergone penetrating keratoplasty between August 2000 and December 2002. The patients were classified into three groups based on the state of the corneal endothelium. Changes in cell density, polymorphisms, and polymegathism of the donor cornea were compared between groups. Results were analyzed by ANOVA. Results: The overall corneal endothelial cell density after grafting was lower, but the differences in endothelial cell states between the recipient cases were not statistically significant. The change in corneal endothelial cell density showed a significantly higher difference (p=0.0013) when patients had either undergone a rejection episode during recovery or recurred herpetic uveitis. Conclusions: The preoperative state of the corneal endothelium may affect the survival of donor corneal endothelium after grafting. However, rejection of the transplant contributes more significantly to the survival of the donor corneal endothelium than other factors. We suggest close observation and keen therapy with respect to rejection after grafting.

키워드

Corneal endothelial cell density, Penetrating keratoplasty, Rejection