1,2-비스(디페닐포스티노)에탄을 배위자로 한 항암성백금(II) 착체의 위암세포와 정상신장세포에 대한 선택적 세포독성

• 영문명: Selective Cytotoxicity of Pt (II) Complex Containing 1,2-Bis (diphenylphosphino)ethane on Human Gastric Cancer Cell-Lines and Normal Kidney Cells
• 발행기관: 대한약학회
• 저자명: 노영수(Young Soo Rho) 장성구(Sung Goo Chang) 정지창(Jee Chang Jung)
• 간행물 정보: 『약학회지』제44권 제5호 (2000년), 399~405쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.10.31

영문 초록

We have synthesized a novel platinum (II) coordination complex containing trans-l-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-bis (diphenylphosphino)ethane (DPPE) as a leaving group. In addition, nitrate was added to improve the water-solubility. A new series of [Pt (trans-l-DACH) (DPPE).2NO3(PC) was evaluated for its cytotoxic activity on MKN-45 human gastric adenocarcinoma cells and normal primary cultured kidney cells. PC has demonstrated high levels of cytotoxicity against MKN-45/S, MKN-45/ADR and MKN-45/CDDP cells. The cytotoxicity of PC against rabbit proximal renal tubular cells, human renal cortical cells, and human renal cortical tissues, determined using the MTT assaying technique, the [3H]-thymidine uptake and the glucose consumption tests, was found to be quite less than those of cisplatin. Based on these results, this novel platinum (II) coordination complex appears to be better for improving antitumor activities with low nephrotoxicity and is a valuable lead in the development of new, clinically available anticancer: chemotherapeutic agents.

키워드

Selective cytotoxicity platinum (Ⅱ) coordination complex antitumor activity nephrotoxicity.