긴꼬리말불버섯(Lycoperdon pedicellatum)의 항암 면역활성

• 영문명: Antitumor and Immunomodulatory Activity of Lycoperdon pedicellatum
• 발행기관: 대한약학회
• 저자명: 정경수(Kyeong Soo Chung) 김진향(Jin Hyang Kim)
• 간행물 정보: 『약학회지』제44권 제5호 (2000년), 463~469쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.10.31

영문 초록

Protein-polysaccharide fractions separated from nine Korean wild mushrooms were subjected to an in vitro screening test for lymphoblastogenic activity. Of these, PPLP, the protein-polysaccharide fraction of Lycoperdon pedicellatum, showed the most potent activity, and were further investigated for its antitumor activity. When intraperitoneally injected into ICR mice once daily for six days at a dose of 30mg/kg, PPLP strongly inhibited the growth of sarcoma 180 tumor cells, showing the inhibition ratio of 97.6%. PPLP also showed in vitro inhibitory activity on sarcoma 180 or leukemia L1210 at the concentration of 500mcg/ml or higher. These results strongly suggest that PPLP might exert its antitumor activity through immunostimulation as well as inhibitory activity on the tumor cells.

키워드

Basidiomycetes Lycoperdon pedicellatum PPLP protein-polysaccharide antitumor immunostimulation lymphoblastogenic flow cytometry.