Bacillus lentimorbus B-6 균주로부터 생산된 α-Glucosidase 억제제의 생물 유화제로서의 특성

• 영문명: Emulsifying Character of α-Glucosidase Inhibitor Produced from Bacillus lentimorbus B-6
• 발행기관: 대한약학회
• 저자명: 양용준(Young-Joon Yang) 김경자(Kyoung-Ja Kim)
• 간행물 정보: 『약학회지』제53권 제3호 (2009년), 114~118쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.06.30

영문 초록

Bioemulsifiers are those chemicals which are produced from microorganisms but which have both hydrophilic and hydrophobic groups. α-Glucosidase inhibitor (α-GI) produced from Bacillus lentimorbus B-6 (B-6) showed bioemulsifying activity. But β-glucosidase inhibitor produced from B-6 didn't show emulsifying activity. α-GI was purified from supernatant of B-6 grown in minimal culture medium containing glucose and sodium glutamate by Sephadex G-100 column chromatography and isolated from β-GI by dialysis against water. Toluene was determined as the best substrate for emulsifying activity of α-GI. α-GI showed thermostability at 100oC for 15 min, high salt tolerance up to 32% NaCl and wide range of pH-stability at pH 4~10. Emulsifying character of α-GI can be useful for the liposome formation for the treatment of diabetes mellitus.

키워드

α-glucosidase inhibitor Bacillus lentimorbus bioemulsifier