H2-M3의 세포 표면 발현이 NK 세포의 활성에 미치는 영향 분석

• 영문명: The Cell Surface Expression of H2-M3 Does Not Directly Effect on the Killing Activity of NK Cell
• 발행기관: 대한약학회
• 저자명: 이상열(Sang Yeol Lee) 전태훈(Taehoon Chun)
• 간행물 정보: 『약학회지』제53권 제3호 (2009년), 125~129쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.06.30

영문 초록

H2-M3 (M3) is a unique antigen presenting molecule which provides N-formylated peptide to certain type of T cells. Previous observation indicated that NK cell activity is significantly diminished during listerial infection in H2-M3-/- mice. To explore the possibility that M3 expression directly effect on NK cell activity, we measured NK cell activity with or without stimulation of N-formylated peptide on antigen presenting cells. Results indicated that the expression of M3 is not directly influence on NK cell activity. Further study will be focused on the indirect effect of M3 on regulating NK cell activity.

키워드

antigen presenting molecule H-2M3 (M3) Major histocompatibility complex molecule NK cell N-formylated peptide