2-알킬-2,3-다이하이드로-1H-2-아자사이클로펜타[b]안트라센-5,10-디온계 유도체 합성 및 세포독성

• 영문명: Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H-2-azacyclopenta[b]anthracene-5,10-diones
• 발행기관: 대한약학회
• 저자명: 곽재환(Jae-Hwan Kwak) 정은경(Eun-Kyeong Jeong) 오주훈(Ju Hoon Oh) 정재경(Jae-Kyung Jung) 홍진태(Jin-Tae Hong) 이희순(Heesoon Lee)
• 간행물 정보: 『약학회지』제53권 제1호 (2009년), 41~44쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.02.28

영문 초록

A series of 2-alkyl-2,3-dihydro-1H-2-azacyclopenta[b]anthracene- 5,10-diones (3a~h) were synthesized and evaluated in vitro cytotoxicity against colon cancer cell lines (HCT116 and SW620) and nuroblastoma cell lines (SK-N-SH and SK-N-MC). Among them, compound 3f showed significant cytotoxic activity (IC50 against SK-N-SH; 14.8 μM, IC50 against SK-N-MC; 11.3 μM).

키워드

cytotoxicity 2-azacyclopenta[b]anthracene-5,10-diones