까마귀쪽나무(Litsea japonica)의 HL-60 백혈병 세포 Apoptosis 유도효과

• 영문명: The Effect of Litsea japonica on the Apoptosis Induction of HL-60 Leukemia Cells
• 발행기관: 대한약학회
• 저자명: 김엘비라(Elvira Kim) 부혜진(Hye-Jin Boo) 현재희(Jae-Hee Hyun) 김상철(Sang-Cheol Kim) 강정일(Jung-Il Kang) 김민경(Min-Kyoung Kim) 유은숙(Eun-Sook Yoo) 강희경(Hee-Kyoung Kang)
• 간행물 정보: 『약학회지』제53권 제1호 (2009년), 6~11쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.02.28

영문 초록

This study investigated the antiproliferative effect of the EtOH extract from Litsea japonica. The extract markedly inhibited the growth of HL-60 cells. When treated with the extract, several apoptosis events like as DNA fragmentation, chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. The extract decreased the Bcl-2 expression, whereas the Bax expression was increased. Caspase-9 and -3 were activated and poly (ADP-ribose) polymerase was cleaved. The results suggest that the antiproliferative effect of L. japonica in HL-60 appears to arise from apoptosis induction via the down-regulation of Bcl-2 and the activation of caspases.

키워드

Litsea japonica HL-60 apoptosis Bcl-2 Bax caspases