어성초로부터 분리된 Quercetin의 카드뮴에 대한 독성억제효과

• 영문명: The Inhibitory Effects of Quercetin from Houttuynia cordata against Cadmium-Induced Cytotoxicity
• 발행기관: 대한약학회
• 저자명: 최화정(Hwa Jung Choi) 노용주(Yong Ju No) 강정일(Jeong Il Kang) 백승화(Seung Hwa Baek)
• 간행물 정보: 『약학회지』제53권 제1호 (2009년), 12~18쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.02.28

영문 초록

The aim of this study was to develop antitoxic compound for cadmium-induced cytotoxic Vero cells. These cells were divided into five groups; control group (medium only), cadmium group (cadmium only), and two experimental groups. SRB (sulphorodamine B) assay was performed to evaluate the cytotoxicity of cell organelles. After cadmium was treated on Vero cells, we determined IC50 values to examine the detoxification effects of Houttuynia cordata methanol extract and quercetin under cadmium-induced cytotoxicity. Furthermore, morphological changes were observed by the light microscope. In Vero cells, methanol extract of Houttuynia cordata, and quercetin showed inhibitory effects on cadmium-induced cytotoxicity and these detoxification effects were increased in a concentration-dependent manner. These results suggest that methanol extract and quercetin from Houttuynia cordata retain a potential antitoxic activity.

키워드

Houttuynia cordata quercetin cytotoxicity cadmium Vero cells SRB