황색포도상구균의 테트라사이클린 내성 플라스미드 동정

• 영문명: Characterization of Tetracycline Resistance Plasmids of Staphylococcus aureus
• 발행기관: 대한약학회
• 저자명: 박정희(Jung Hee Park) 이재윤(Jae Yoon Lee) 문경호(Kyung Ho Moon)
• 간행물 정보: 『약학회지』제52권 제4호 (2008년), 279~282쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.08.31

영문 초록

Plasmids were isolated from 15 tetracycline (Tc) resistant S. aureus. Two small tetracycline resistance plasmids, pKH16 and pKH17, have been isolated from Staphylococcus aureus JY10 and Staphylococcus aureus JY22, respectively and the complete nucleotide sequences of those plasmids have been determined. pKH16 consisted of 4,442 bp and showed high identity to pKH6 (99% matching percentage) isolated in 1989 from S. aureus SA2. pKH17 consisted of 4,441 bp and showed less identity to pKH6 (95% matching percentage) than pKH16. PCR analysis showed that tetK and tetM did not exist in ten large plasmids isolated from ten Tc resistant S. aureus. Twelve Tc resistant S. aureus showed reistance both to Tc and Mn and we might analogize that twelve Tc resistant S. aureus had tetM in their chromosome.

키워드

Staphylococcus aureus tetracycline resistant plasmid PCR tetK tetM minocycline