황촉규 추출물의 Nitric Oxide 생성 저해활성

• 영문명: Inhibition of Nitric Oxide Production by the Extracts of Hibiscus manihot
• 발행기관: 대한약학회
• 저자명: 박은영(Eun Young Park) 양기숙(Ki Sook Yang)
• 간행물 정보: 『약학회지』제52권 제4호 (2008년), 259~263쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.08.31

영문 초록

Anti-inflammatory activity of the extracts of Hibiscus manihot was investigated through the evaluation of its inhibitory effect on the production of inflammatory biomarkers (i-NOS, COX-2) in RAW264.7 murine macrophage cells. Among the sequential solvent fractions (hexane, dichloromethane, ethyl acetate, n-butanol and water), the fractions of dichloromethane (1 μg/ml) and ethyl acetate (5 μg/ml) showed potential inhibitory activities on i-NOS and COX-2 activity in RAW264.7 cells. These results suggest that Hibiscus manihot might have an anti-inflammatory activity through the suppression of inflammatory markers.

키워드

Hibiscus manihot i-NOS COX-2 RAW264.7 cells