벤조산과 관련 화합물의 구강암 세포주에 대한 세포독성효과

• 영문명: The Cytotoxic Effect of Benzoic Acid and Related Compounds against Oral Cancer Cell Lines
• 발행기관: 대한약학회
• 저자명: 한두석(Du Seok Han) 박윤규(Yeun Kju Park) 강정일(Jeong Il Kang) 백승화(Seung Hwa Baek)
• 간행물 정보: 『약학회지』제52권 제4호 (2008년), 252~258쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.08.31

영문 초록

The cytotoxic effect of benzoic acid and related compounds on the growth of normal cell lines and human oral epithelioid cell line was evaluated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and 2,3-bis- [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-caboxanilide (XTT) methods. 3,4,5-Trihydroxybenzoic acid decreased the cell viability of human oral epithelioid cells and the cell adhesion activity of human oral epithelioid cells. Under the light microscopy, 100 μM 3,4,5-trihydroxybenzoic acid showed the highest cytotoxic activity. From these results, we can propose that 3,4,5-trihydroxybenzoic acid has a potential anticancer activity.

키워드

benzoic acid cell viability cell adhesion activity cytotoxicity