Helicobacter pylori의 전사조절인자인 Fur 단백질과 Metronidazole 저항성

• 영문명: Transcriptional Regulatory Protein Fur of Helicobacter pylori and its Role in Metronidazole Resistance
• 발행기관: 대한약학회
• 저자명: Douglas E. Berg 최성숙(Sung Sook Choi)
• 간행물 정보: 『약학회지』제52권 제3호 (2008년), 225~231쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.06.30

영문 초록

To clarify effects of the structural changes if Fur protein on the resistance to metronidazole(MTz), the mutational analysis of structure and function of the protein in Helicobacter pylori (Hp) was undertaken. It was identified that some changes in Hp Fur protein resulted in increase og resistance to Mtz, and other changes resulted in decrease of resistance. Increase of Mtz resistance came from the enzyme's decreased ability of reducing prodrug Mtz to the form of bactericidal agent. Some sites that affects Mtz resistance (i) in Fur's N terminal extension, and (ii) in its central region, which links DNA binding and Fe-binding modules were identified. It was also found that the FLAG tag to Fur's C terminus also significantly impairs Fur function.

키워드

H. pylori Fur protein metronidazole resistance