Insulin Receptor Substrate 1의 세린731 인산화 억제를 통한 살리실산의 인슐린저항성 개선효과 기전

• 영문명: Salicylate Enhances Insulin Signaling by Preventing Ser731 Phosphorylation of Insulin Receptor Substrate 1
• 발행기관: 대한약학회
• 저자명: 이용희(Yong Hee Lee)
• 간행물 정보: 『약학회지』제52권 제3호 (2008년), 182~187쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.06.30

영문 초록

Salicylate (SA) was shown to alleviate insulin resistance. Here, we showed that SA inhibited Ser731 phosphorylation of insulin receptor substrate (IRS1) and S6 kinase activation, and enhanced tyrosinase phosphorylation of IRS1 in response to insulin or amino acid. Experiments using a cJun N-terminal kinase (JNK)-deficient cell and an IRS1 JNK-binding mutant showed that JNK is not required for Ser731 phosphorylation. A two-week treatment of obese mice with SA resulted in decreased Ser731 phosphorylation and enhanced insulin signaling. These results suggest that SA enhanced insulin signaling by inhibiting Ser731 phosphorylation of IRS1.

키워드

IRS1 insulin salicylate phosphorylation