새로운 플루오로 퀴놀론계 항균제에 대한 내성 MRSA 균주의 In Vitro 선발과 그 내성 기전 분석

• 영문명: In Vitro Selection of MRSA Strains Resistance to Some New Fluoroquinolone Antibiotics and Characterization of their Resistance Mechanisms
• 발행기관: 대한약학회
• 저자명: 윤은정(Eun Jeong Yoon) 김현지(Hyun Jee Kim) 이춘영(Chun Yeong Lee) 최응칠(Eung Chil Choi) 심미자(Mi Ja Shim)
• 간행물 정보: 『약학회지』제52권 제3호 (2008년), 219~224쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.06.30

영문 초록

Clinically isolated methicillin-resistance Staphylococcus aureus strains were exposed to subinhibitory concentration of DW286, DW-224a, gemifloxacin, trovafloxacin, sparfloxacin and ciprofloxacin during 26- to 39-days period. Subculturing led to resistance development, and most of the selected mutants were above susceptible breakpoints. Selected mutants had broad cross resistance to other quinolone antibiotics and only one mutant was completely susceptible to all fluoroquinolones. Twenty five among 42 mutants revealed mutation on DNA gyrase and topoisomerase Ⅳ and action of efflux pumping out system are the resistance mechanism of DW-224a.

키워드

quinolone DNA gyrase topoisomerase Ⅳ MRSA QRDR