RBL 2H3 비만세포에서 히스타민 유리와 칼슘과의 관계

• 영문명: Relationship Between Histamine Release and Ca2+ Mobilization in RBL 2H3 Mast Cells
• 발행기관: 대한약학회
• 저자명: 박성훈(Sung Hun Park) 김수정(Soo Jeong Kim) 김정민(Jung Min Kim) 박주현(Ju Hyun Park) 최방실(Bang Shil Choi) 이지윤(Ji Yun Lee) 최미영(Mi Yeong Choi) 심상수(Sang Soo Sim)
• 간행물 정보: 『약학회지』제51권 제1호 (2007년), 63~67쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.02.28

영문 초록

To investigate the relation between extracellular Ca2+ and histamine release, we observed agonist-induced histamine release from RBL 2H3 mast cells in the presence or absence of extracellular Ca2+ concentration. Histamine release induced by melittin and thapsigargin were greater in the presence of extracellular Ca2+ than in the absence of extracellular Ca2+. Econazole-induced histamine release had nothing to do with extracellular Ca2+, whereas arachidonic acid-induced histamine release increased in the absence of extracellular Ca2+. Calmodulin antagonists did not affect melittin-induced histamine release but they may potentiate arachidonic acid-induce histamine release. These data suggest that arachidonic acid-induced histamine release may be mediated via Ca2+ -independent pathway and may be potentiated by the block of Ca2+ -dependent pathway.

키워드

mast cells histamine calcium calmodulin antagonist