Cyclooxygenase-1과 Cyclooxygenase-2에 대한 4,5-Diarylpyrroles의 Docking Mode

• 영문명: Docking Mode of 4,5-Diarylpyrroles into Cyclooxygenase-1 and Cyclooxygenase-2
• 발행기관: 대한약학회
• 저자명: 이종달(Jong Dal Rhee) 도성탁(Seong Tak Doh) 구본기(Bon Ki Koo)
• 간행물 정보: 『약학회지』제43권 제6호 (1999년), 776~781쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.12.28

영문 초록

Dockings of 4,5-diarylpyrrroles into cyclooxygenase-1 and cyclooxygenase-2 were carried out by GOLD program. The sulfonyl groups bonded to 5-phenyl ring of 4,5-diarylpyrrroles are directed to Arg513 of COX-2 and Tyr385 of COX-1. COX-2 docking modes of pyrroles are different from COX-1. Tyr385 and Argl2O of COX-1 and COX-2 have been recognized as important residues. Val523 of COX-2 may be also important. A new COX-2 selective inhibitors could be designed from the docking study.

키워드

Docking mode 4,5-diarylpyrroles cyclooxygenase-1 cyclooxygenase-2.