Flavin mononucleotide를 탈리기로한 백금(II) 착체의 합성과 그 항암활성

• 영문명: Synthesis of Pt(II) Complexes containing Flavin mononucleotide as Leaving Ligand and their Anticancer Activity
• 발행기관: 대한약학회
• 저자명: 권영이(Y. E. Kwon) 황규자(K. J. Whang)
• 간행물 정보: 『약학회지』제43권 제6호 (1999년), 762~770쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.12.28

영문 초록

A series of vitamin-containing PT(II) complexes of the type [Pt (FMN) (L)] (FMN=flavin mono-nucleotide, L=ethylenediamine, 1,3-propanediamine, 1,4-bu- tanediamine) was synthesized and characterized by IR, electronic absorption, elemental analysis and FAB-Mass. The coordination sites of FMN to PT(II) ions were determined to be N(5) and 0(6) with resultant chelate ring formation. Theses compounds have much better water solubility (30-35mg/ml) than cisplatin (1mg/ml). The anticancer activity of this vitamin-containing PT(II) series was investigated by MTT assay against mouse and human leukemia cell lines in vitro. Among these compounds, FMN (1,4-butanediamine) PT(II) having seven-membered ring structure as amine ligand showed moderate anticancer activity.

키워드

Water-soluble Pt(Ⅱ) complex vitamin anticancer activity cisplatin.