UVB조사에 의한 페플록사신의 광독성 유발 기전

• 영문명: Phototoxic Potential Mechanism of Pefloxacin Irradiated by UVB
• 발행기관: 대한약학회
• 저자명: 최윤수(Yoon Soo Choi) 이경선(Kyung Seon Lee)
• 간행물 정보: 『약학회지』제43권 제6호 (1999년), 703~708쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.12.28

영문 초록

The effect of antioxidants on photochemical reaction of pefloxacin by UVB (290~320nm) was investigated and the possible mechanism of phototoxicity on the skin was also studied. The photodegradation of pefloxacin by UVB was suppressed by cysteine, reduced glutathione and ascorbic acid, but was promoted by alpha-tocopherol. Squalene, accounts for more than 10% of skin surface lipids, was peroxidized by pefloxacin through both radical and singlet oxygen mechanism.

키워드

UVB phototoxicity pefloxacin.