상백피로부터 분리한 면역세포 증식작용을 지닌 다당체

• 영문명: Isolation of Lymphocyte Proliferating Polysaccharide from Mori Cortex Radicis
• 발행기관: 대한약학회
• 저자명: 김철영(Chul Young Kim) 이은주(Eun Ju Lee) 김환묵(Hwan Mook Kim) 허훈(Hoon Huh)
• 간행물 정보: 『약학회지』제42권 제4호 (1998년), 467~471쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.08.31

영문 초록

Numerous efforts have been made to isolate immunologically active component from Mori Cortex Radicis, since it has been used in the treatment of bronchial asthma, and immune disorder in human. Recently, we reported the purification of an anti-allergic component of the Mori Cortex Radicis. Among the fractions we prepared in the previous study, a fraction was active in the proliferation of murine lymphocytes. The active component (HHM 3-1) was elucidated as a polysaccharade with a small amount of lignin. When it was subjected to MALDI-MS by using 3-hydroxypicolinic acid as a matrix, the molecular weight of the component was estimated as 792688.2dalton. Total hexose and protein content of the component were estimated as 62.6% and 0.51%, respectively and it was composed mainly of glucose, galactose and mannose. The remaining part of the component was estimated as ligin because of the characteristic functional groups in IR and UV spectra. Concomitant treatment of HHM 3-1 with known mitogens synergistically increased the proliferation of B-cells and T-cells.

키워드

Mori Cortex Radicis the proliferation of murine lymphocytes polysaccharide(HHM 3-1).