별불가사리 렉틴의 복수암에 대한 항암효과

• 영문명: Antitumor Effect of Asterina pectinifera Lectin on Ascitic Tumor
• 발행기관: 대한약학회
• 저자명: 손윤희(Yun Hee Shon) 전경희(Kyung Hee Jeune) 최수정(Soo Jeong Choi) 정시련(See Ryun Chung)
• 간행물 정보: 『약학회지』제42권 제4호 (1998년), 388~394쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.08.31

영문 초록

The lectin from starfish, Asterina pectinifera, was purified and tested for its potential antitumor activity. It was shown to possess considerable toxicity toward various tumor cell lines. Concentration of Asterina pectinifera lectin (APL) at 4mg/5 x 10 cells resulted in 28% death of Ehrlich ascites tumor cell, 40% of L929, 60% of A549, and 52% of HeLa cells after 48 hours incubation. Toxicity of APL to L929, Ehrlich ascites, A549, and HeLa cells revealed a reduction in cell viability of approximately 70% at APL concentration of 8mg/5 x 105 cells after 48 hours incubation. Administration of APL (100mcg/day or 300mcg/day) inhibited the growth of Ehrlich ascites cells in vivo. Mice given only Ehrlich cells survived an average of 15+/-1 (S.E.) days. Mice given Ehrlich cells and 100mcg or 300mcg APL had 58% and 67% survival, respectively, after 20 days. These results suggest that APL has antitumor activity.

키워드

Antitumor activity Asterina pectinifera cell toxicity lectin.