천연물에서 단리한 식물정제 탄닌의 항암효과 및 생물학적 반응 조절 물질로서의 기능 검색

• 영문명: Antitumor Effect of Natural Products, Purified Tannin from Plants and Screening of BRM function
• 발행기관: 대한약학회
• 저자명: 이도익(Do Ik Lee) 조장현(Jang Hyun Cho) 이민원(Min Won Lee)
• 간행물 정보: 『약학회지』제42권 제4호 (1998년), 354~352쪽, 전체 -1쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.08.31

영문 초록

Praecoxin A, an ellagitannin, purified from Alnus hirsuta var.microphlla was evaluated on the antitumor activity. Praecoxin A had the significant cytotoxicity to six tumor cell lines: human chronic myelogenous leukemia K-562, human promyelocytic leukemia HL-60, mouse leukemia P388, mouse lymphocytic leukemia L-1210, sarcoma-l8O, mouse lymphoma L5178Y except L-1210. And the most sensitive cell line was K-562 (ED50=2.43mcg/ml). The ED50 of praecoxin A against HL-60, P388, L-1210, sarcoma7l8O and L5178Y were 6.28, 8.66, 10.00, 7.01, 9.32mcg/ml, respectively. Praecoxin A showed the increasing effect in life span by 36.8% on the 1st day after treatment of 10mg/kg in mice bearing sarcoma-180 tumor cells (ascitic form) via NCI (National Cancer Institute, U.S.A.) protocol in vivo assay. As a result, praecoxin A is considered to show the antitumor activity.

키워드

Praecoxin A Ellagitannin Antitumor activity.