사람 융모 성선 자극 호르몬에 의한 복강 대식세포로부터 산화질소의 발생

• 영문명: Nitric Oxide Generation from Peritoneal Macrophages by Human Chorionic Gonadotropin
• 발행기관: 대한약학회
• 저자명: 이은희(Eun Hee Lee) 신태용(Tae Yong Shin) 김형민(Hyung Min Kim)
• 간행물 정보: 『약학회지』제41권 제3호 (1997년), 365~369쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.06.30

영문 초록

Human chorionic gonadotropin (hCG) is a placental hormone and is involved in maintenance of the corpus luteum during pregnancy. In the present study, effect of hCG on nitiric oxide (NO) generation from peritoneal macrophage was examined. hCG ahd no effect on NO generation by itself, whereas recombinant interferon-gamma (rIFN-gamma) alone had modest activity. When hCG was used in combination with rIFN-gamma, there was a marked cooperative induction of NO generation in a dose-dependent manner. The optimal effect of hCG on NO generation was shown at 6 hr after treatment with rIFN-gamma. Furthermore, northern blot analysis of showed that hCG increased the expression of inducible NO synthase(iNOS) gene. These results suggest that hCG induces NO generation from macrophages by increasing the expression of iNOS gene.

키워드

Nitric oxide human chorionic gonadotropin macrophage.