재조합 인간 상피세포성장인자(DWP401)의 흰쥐에서의 약물동태

• 영문명: Pharmacokinetics Of Recombinant Human Epidermal Grouth Factor (DWP401) in Rats
• 발행기관: 대한약학회
• 저자명: 정주영(Joo Young Chung) 고여욱(Yeo Wook Koh) 남권호(Kwon Ho Nam) 조재열(Jae Youl Cho) 박승국(Seung Kook Park) 유영효(Young Hyo Yu) 김재환(Jae Hwan Kim) 한건(Kun Han) 박명환(Myung Hwan Park) 심창구(Chang Koo Shim)
• 간행물 정보: 『약학회지』제41권 제3호 (1997년), 328~334쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.06.30

영문 초록

Pharmacokinetics of DWP401, a recombinant human epidermal growth factor (rhEGF), was studied using radioimmunoassay (RIA) and 125I-DWP401 in rats. When DWP401 was administered i.v. at doses of 50 and 500 mcg/kg, the plasma DWP401 disappeared biiexponentially with terminal half life of 4.7 and 92.8 min. The Cmax and Tmax after s.c. administration of ti at doses of 50 and 500 mcg/kg were determined to be 23.6 and 17.5 ng/ml at 50 mcg/kg, and 261.4 ng/ml and 36.8 min, respectively. Both the total urinary and biliary recoveries of intact DWP401 2343 very low (<0.4%), probably due to its extensive degradation in the body. the concentration ratio of DWP401 between the organ and plasma decreased especially in the liver and kidney as the dose and time after the dose increased. For example, the liver/plasma and kidney/plasma concentration ratio of DWP401 at 2.5 min after i.v. doses of 50 mcg/kg were comparable and much larger than unity. But, the ratio at 2.5 min after i.v. doses of 500mcg/kg was much larger in the kidney that in than in the liver. These results suggest that the systemic administration of DWP401 might be subject to rapid and extensive clearance from circulation within several hour after main distrbution to liver and kidney.

키워드

DWP401 recombinant human epidermal growth factor pharmacokinetics rat