우리나라에서 남용되는 메스암페타민의 거울상 이성질체분리

• 영문명: Enantiomeric Separation of Methamphetamine Abused in Korea
• 발행기관: 대한약학회
• 저자명: 유영찬(Young Chan Yoo) 정희선(Hee Sun Chung) 최화경(Hwa Kyung Choi) 김은미(Eun Mi Kim) 김미경(Mi Kyung Kim) 김선춘(Sun Choon Kim)
• 간행물 정보: 『약학회지』제41권 제3호 (1997년), 277~282쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.06.30

영문 초록

Methamphetamine, which is the most commonly abused drug in Korea, exists in terms of d-, l- isomers and a racemate(dl). d-Methamphetamine is a potent central nervous system stimulant, whereas l-Methamphetamine is sold freely as a nasal decongestant. In addition, methamphetamine appears in different ratios of optical isomers by the clandestine synthesis applied. In this study, enetiomeric separation of methamphetamines was estabilished to distinguish the chirality of methamphetamines trafficked and abused in Korea. A gas chromatograph/mass spectrometer(GC/MS) system equipped with an achiral capillary column is used to isolate the isomers of methamphetamine after (S)-N-(trifluoroacetyl)-l-prolyl(TFP) deravatization.After analyzing 10 illicit methamphetamine powders and 10 positive urine samples, following findings were found: d-Methamphetamine was well resolved from l-Methamphetamine by chromatographic separation of TFP derivatibes on DB-5 with retention time of 11.80 and 11.35 min respectively. The detection of d-Methamphetamine in all 10 powders and 10 urine samples proves that all methamphetamines abused in Korea are illegally manyfactured and administred.

키워드

d-methamphetamine l-methamphetamine enantiomerics eparation (S) -N-(trifluoroace-tyl)-l-prolyl derivatization.