상피세포 성장인자를 함유한 외용 겔 제제의 특성 및 창상 치유 효과

• 영문명: Topical Gel Formulations of Epidermal Growth Factor and Their Wound Healing Effects
• 발행기관: 대한약학회
• 저자명: 이정우(Jung Woo Yi) 김희준(Hee Jun Kim) 조성완(Seong Wan Cho) 박준상(Jun Sang Park) 최영욱(Young Wook Choi)
• 간행물 정보: 『약학회지』제40권 제4호 (1996년), 411~417쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.08.31

영문 초록

Epidermal growth factor(EGF), a potential healing agent for wounds and burns, has been formulated to topical gels with the hydrophilic polymers, Carbopol 934P. Physicochemical characteristics of the aqueous gels were evaluated by rheological properties and pH changes on storage. The gels were relatively stable at 4oC and room temperature showing no changes in pH for two weeks, and revealed the rheogram of shear thinning plastic flow with the yield values in the range of 40 to 70dyne/cm2. In vivo healing effects of different gel formulations have been compared with water-soluble and oleaginous ointments in full-thickness wound mouse model. The gel systems resulted in better wound healing effects than the other ointments. Furthermore, liposomal Carbopol gel has been developed by the addition of EGF-containing liposomal suspension into the Carbopol gel. The enhanced wound healing effects have been observed in the liposomal gel system, compared to the other gels and conventional ointments.

키워드

Epidermal growth factor Wound healing Carbopol Gels Plastic flow Ointments Topical preparation.