X-Ray 단결정체 분석에 의한 6,7-디클로로퀴놀린-5,8-디온의 친핵치환반응

• 영문명: Nucleophilic Substitution of 6,7-Dichloroquinoline-5,8-dione by X-ray Crystal Structure Analysis
• 발행기관: 대한약학회
• 저자명: 서명은(Myung Eun Suh) Clifford George
• 간행물 정보: 『약학회지』제40권 제4호 (1996년), 382~386쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.08.31

영문 초록

The compound of the 6,7-dichloroquinoline-5,8-dione has two asymmetric chloro radicals at the position of the C6 and C7. When the compound reacts with ethyl acetoacetate in the presence of sodium ethoxide, it is considered that C6 and/or C7 position of the compound can be substitued. The exact substitued position of the product (I) could not be identified by the NMR analysis in our experiment. Therefore, we synthesized the 3-ethoxycarbonyl-2-methyl-1-N-propyl pyridino(2,3f)indole-4,9-dione by reaction of the product (I) with propylamine via intramolecular cyclization to identify the substitued position of the product (I) using the X-ray crystallographic structure analysis. The result demonstrates that the position of nucleophilic substitution of the product (I) is at the position of the C6.

키워드

X-ray crystal structure analysis of 3-ethoxycarbonyl-2-metliyl-lN-propyl-pyridino(2.3f)indole- 4.9-dione 6-(α-acetyl-α-ethoxycarbonyl-methyl)-7-chloroquinoline-5.8-dione.