플루오로퀴놀론계 항생제인 DWP20373의 in vitro 항균작용

• 영문명: Evaluation of in vitro Antibacterial Activity of DWP20373, a Novel Fluoroquinolone
• 발행기관: 대한약학회
• 저자명: 김지연(Ji Yeon Kim) 최문정(Moon Jung Choi) 한승희(Seung Hee Han) 김병오(Byung O Kim) 심점순(Jeom Soon Shim) 정연의(Yeon Eui Jung) 이재욱(Jae Wook Lee) 유영효(Young Hyo Yu) 박명환(Myung Hwan Park)
• 간행물 정보: 『약학회지』제40권 제3호 (1996년), 357~368쪽, 전체 12쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.06.30

영문 초록

The in vitro antibacterial activity of a novel fluoroquinolone, DWP20373(1-Cyclopropyl-6-fluoro-8-methoxy-7-(2,7-diazabicyclo[3,3,0]oct-4-ene-7-yl)-1,4-dihydro-4 oxoquinoline-3carboxylic acid) was compared with those of ciprofloxacin (CPFX), sparfloxacin (SPFX) and ofloxacin (OFLX). DWP20373 was more active than SPFX and OFLX but was less potent than CPFX against gram-negative bacteria. DWP20373 showed an excellent activity against L-MRSA and H-MRSA (MlC90=0.781~1.563mcg/ml).The activity of DWP20373 decreased moderately in the presence of 5mM Mg2+. However, pH and serum had no effect on the activity of DWP20373. DWP20373 possessed a rapid bactericidal activity against gram-positive and gram-negative strains.

키워드

DWP20373 MIC Killing curve pH effect Serum effect.