새로운 퀴놀론 항생제 LB20304의 Post-Antibiotic Effect

• 영문명: Post-Antibiotic Effect of LB20304, A New Quinolone Antibiotic
• 발행기관: 대한약학회
• 저자명: 안미정(Mi Jeong Ahn) 백경숙(Kyung Sook Paek) 김무용(Mu Yong Kim) 김인철(In Chull Kim) 곽진환(Jin Hwan Kwak)
• 간행물 정보: 『약학회지』제40권 제3호 (1996년), 347~350쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.06.30

영문 초록

The post-antibiotic effect (PAE), which is defined as the period of time lag that the target organisms resume normal growth rate after complete removal of the antibiotics, of LB20304 and ciprofloxacin was evaluated against Staphylococcus aureus 6538p and Escherichia coli 3190Y, respectively. The PAE was estimated by adding each antibiotic to a log phase of growth and incubating at 37oC for 1 h.Antibiotic was removed by centrifugation, and total viable cell counts were determined hourly for a further 10 h. The PAEs of LB20304 against S. aureus at concentrations of 1XMIC and 2mcg/ml were 10 min and 93min, respectively. LB20304 showed a comparable PAE to ciprofloxacin. Against E. coli, the PAE of LB20304 was also similar to that of ciprofloxacin at concentration of 4XMIC but it was much longer than that of ciprofloxacin at concentration of 2mcg/ml. LB20304 showed higher lethality than ciprofloxacin against both S. aureus and E. coli strains.

키워드

Post-Antibiotic Effect(PAE) LB20304 Quinolone Lethality.