개오가피의 성분 및 항암효과

• 영문명: Chemical Components of Acanthopanax divaricatus and Anticancer Effect in Leaves
• 발행기관: 대한약학회
• 저자명: 육창수(Chang Soo Yook) 노영수(Young Soo Rho) 서성훈(Seong Hoon Seo) 임재윤(Jae Yoon Leem) 한덕용(Dug Ryong Han)
• 간행물 정보: 『약학회지』제40권 제3호 (1996년), 251~261쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.06.30

영문 초록

Acanthopanax divaricatus Seem. is a medicinal plant growing widely through out Korea, Japan and China. The plant material of Acanthopanax spp. is used as analgesic, tonic, sedative drug as well as for the treatment of hypertension, rheumatism and diabetes. From the stem barks and root barks of A. divaricatus, diterpenoid compound was isolated and identified as pamaric acid (C20H30O2, mp 164oC), lignan compounds were isolated and identified as d-sesamin (C20H18O6, mp 123-124oC), eletheroside E (C34H46O18, mp 257-259oC), three sterol compounds were identified as beta-sitosterol, campesterol, stigmasterol, and six fatty acid compounds were identified as stearic acid, palmitic acid, oleic acid, linolenic acid, arachidonic acid and behenic acid. And also leaves of A. divaricatus, chiisanoside were identified, one of secotriterpenoidal compound(white amorphorous powder crystal, mp 228oC). Anticancer activity and nephrotoxicity were tested by MTT assay. Anticancer effect of chiisanoside was much lower than that of cisplatin.

키워드

Acanthopanax divaricatus pirxiaric acid d-sesamin oleanolic acid eleutheroside E chiisanoside β-sitosterol campesterol stigmasterol stearic acid palmitic acid oleic acid linolenic acid arachidonic acid behenic acid etc.