효모에서 발현된 유전자 재조합 GM-CSF의 일반 약리작용

• 영문명: General Pharmacology of Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor Expressed in Saccharomyces cerevisiae
• 발행기관: 대한약학회
• 저자명: 이은방(Eun Bang Lee) 김운자(Oon Ja Kim)
• 간행물 정보: 『약학회지』제35권 제2호 (1991년), 135~141쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.04.30

영문 초록

The general pharmacological tests with rhGM-CSF indicated that it had no influences on rotarod and locomotor activity tests, but shortened hexobarbital-sleeping time at the large dose of 3mg/kg, s.c. in mice. It elicited no hypothermic, analgesic and antiepileptic action. No influences on blood pressure and respiration in rabbits were observed at the dose of 1mg/kg, i.v. and it did neither affect the receptors of adrenaline, acetylcholine, serotonin, histamine, kinin and oxytocin, nor antagonize the actions of histamine, serotonin and oxytocin at its concentrations of 1X10-6g/ml. However, this substance was demonstrated to stimulate the formation of leucocytes in rats.

키워드

rhGM-CSF general pharmacology leucocyte formation.