동물성 소염진통제(I) -구인다당체분획의 소염,진통 및 면역억제작용-

• 영문명: Anti-inflammatory Agents from Animals(I) - Anti-inflammatory, Analgesic and Immunosuppressive Activities of Earthworm Allolobophora caliginosatrapezoides Polysaccharide Fractions -
• 발행기관: 대한약학회
• 저자명: 김창종(Chang Johng Kim) 최윤석(Yun Seuk Choi) 조승길(Seung Kil Cho)
• 간행물 정보: 『약학회지』제35권 제2호 (1991년), 123~130쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.04.30

영문 초록

Effects of Allolobophora caliginosatrapezoides (Ac) polysaccharide fractions on the inflammation and hypersensitivity were studied in vivo. It showed that Ac polysaccharide fractions have the significant inhibitory activities of inflammation and hypersensitivity; They inhibited significantly the carrageenin-induced paw edema and acetic acid-induced writhing syndrome. They also inhibited significantly the Arthus reaction and delayed hypersensitivity in the sheep red blood cell-sensitized mice in accordance with the inhibition of haemaglutinin titer, haemolysin titer, plaque-forming cells and rosette-forming cells. They also improved markedly the oxazolone-induced dermatitis in rats dose-dependently. As the above results, it exhibited that Ac polysaccharide fraction inhibited not only humoral immune response, but also cell-mediated immune response. It seemed that methanol and ether extracts have also another physiological active agents.

키워드

Allolobophora caliginosatrapezoides polysaccharide anti-inflammatory and analgesic action anti-hypersensitivity sheep red blood cell-mediated hypersensitivity Arthus reaction haemaglutinin titer haemolysin titer plaque-forming cells rosette-forming cells delayed hypersensitivity oxazolone-induced dermatitis.