Ibuproxam의 합성

• 영문명: Synthesis of Ibuproxam
• 발행기관: 대한약학회
• 저자명: 최홍대(Hong Dae Choi) 마정주(Jung Joo Ma)
• 간행물 정보: 『약학회지』제35권 제2호 (1991년), 119~122쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.04.30

영문 초록

A convenient method for the synthesis of ibuproxam, which is a non steroidal antiinflammatory agent, is reported. Friedel-Crafts reaction of isobutylbenzene with ethyl alpha-chloro-alpha-(methylthio)acetate (3) gives ethyl alpha-methylthio-(p-isobutylphenyl) acetate (4). Ethyl 2-methylthio-2-(4-isobutylphenyl) propionate (5) is obtained from methylation of the compound (4) with NaH and MeI. Ibuproxam (7) is easily synthesized by reductive desulfurization of the compound (5) with zinc dust-acetic acid or Raney nickel, followed by treatment of the resultant ethyl 2-(4-isobutylphenyl) propionate (6) with H2NOH-HCl.

키워드

Ibupronxam a non-steroidal anti-inflammatory agent Friedel-Crafts reaction methylation desulfurization