병원성 원생동물의 변이와 약물내성: Leishmania major의 클로로퀸 내성

• 영문명: Drug Resistance in Protozoan Parasites : Chloroquine Resistance in Leishmania major
• 발행기관: 대한약학회
• 저자명: 전경희(Kyung Hee Jeune) 정시련(See Ryun Chung) 바바라 밀러(Barbara Miller) 캐롤 시블리(Carol Sibley)
• 간행물 정보: 『약학회지』제35권 제2호 (1991년), 111~118쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1991.04.30

영문 초록

A comparative study was performed on two different strains of Leishmania majorchloroquine sensitive strains (ChlS) and its mutant chloroquine resistant strains (ChlR). ChlR strains were obtained at 5X10-4M chloroquine. Remarkable differences were observed at the initial chloroquine uptake in ChlR and ChlS, ie., the rate of uptake was very reduced in ChlR (Km values were 70nM and 125nM, respectively). Influx and accumulation of chloroquine were also compared between wild type and mutant. An increasing tendency in both influx and accumulation of chloroquine was shown in ChlS, but ChlR demonstrated a rapid release after a little uptake (influx) at the early stage. This result is thought to be basis of their resistance for ChlR strains.

키워드

Drug resistance protozoan parasites malaria Leishmania plasmodium