2(2'',2''-디에톡시 에틸)아미노벤즈아미드 유도체의 고리화반응(II)

• 영문명: Cylization Reaction of 2(2'',2''-diethoxy ethyl)Aminobenzamide derivatives (II)
• 발행기관: 대한약학회
• 저자명: 유희원(Hee Weon Yoo) 이진화(Jin Wha Lee) 서명은(Myung Eun Suh)
• 간행물 정보: 『약학회지』제33권 제4호 (1989년), 246~252쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.08.25

영문 초록

2-Amino-1-N-methyl benzamide, 2-N-benzyl amino benzamide, 2-N-phenyl amino benzamide of 2-amino benzamide derivatives were reacted with alpha-bromo acetaldehyde diethyl acetal in basic condition. 2-N-alkylated products were prepared from 2-amino-1-N-methyl benzamide and 2-N-phenyl amino benzamide. 1-N-benzyl-1,4-benzodiazepin-5-one was prerpared from 2-N-benzyl aminobenzamide via intramolecular cyclization. However, 2-amino-1-N-methyl benzamide with sodium amide did not react to 1,4-benzodiazepin-5-one derivative but 3-methyl-quinazoline-2,4-dione was obtained.

키워드

2-Amino-1-N-methyl benzamide 2-N-benzyl amino benzamide 2-N-phenyl amino benzamide 1-N-benzyl-l 4-benzodiazepin-5-one intermolecular cyclization 2-amino-l-methyl benzamide.