약물과 PVC Infusion Bag과의 상호작용

• 영문명: Interactions between Drugs and Polyvinyl Chloride Infusion Bags
• 발행기관: 대한약학회
• 저자명: 한건(Kun Han) 조영화(Young Hwa Cho) 문동철(Dong Chul Moon)
• 간행물 정보: 『약학회지』제33권 제4호 (1989년), 211~218쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.08.25

영문 초록

Twenty-six injectable drug products, many of which are administered by i.v. infusion, were studied for loss from aqueous solutions stored in polyvinyl chloride (PVC) infusion bags for various periods of time. The PVC infusion bags were stored in the dark room at room temperature for up to one month. Drugs stored in glass bottle served as controls. The solutions were assayed Spectrophotometrically at regular intervals. The effect of drug concentration and pH on the loss of drug from solution were studied. Octanol-water partition coefficients were used as a guage of lipid solubility of drugs. The elution of di(2-ethylhexyl)phthalate(DEHT) from PVC infusion bags was studied. For most of the drug studied, minimal loss from the aqueous solutions were observed over periods of storage time. Six of the drug products - Thiopental sodium, Hydralazine HCl, Thioridazine HCl, Trifluoperazine 2HCl, Metronidazole, Chlorpromazine HCl - were found to be lost a substantial extent. DEHP was found to be migrating from PVC infusion bags.

키워드

PVC infusion bag sorption concentration pH partition coefficients