1,4-디하드로피리딘 산류의 합성(II)

• 영문명: Synthesis of 1,4-Dihydropyridine Carboxylic Acids (II)
• 발행기관: 대한약학회
• 저자명: 서정진(Jung Jin Suh) 홍유화(You Hwa Hong)
• 간행물 정보: 『약학회지』제33권 제4호 (1989년), 219~225쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.08.25

영문 초록

2,6-dimethyl-4-(3''-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-(2''-methylthio)ethyl ester methyl iodide salt (7a) was hydrolyzed by treatment with NAOH in aquous EtOH solution to give 2,6-dimethyl-4-(3''-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid mono methyl ester (2b) in 88% yield. By the same procedure, 2,6-dimethyl-4-(3''-nitrophenyl)-1,4-dihydropyridinine-3,5-dicarboxylic acid 3-mono isopropyl ester (2c), 2,6-dimethyl-4-(2''-nitrophenyl)1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2d), 2,6-dimethyl-4-(2'',3''-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2e) and 2,6-dimethyl-4-(3''-nitrophenyl)-1,4-dihydropyridin-3,5-dicarboxylic acid (2f) were obtained from the methyl iodide salts in 91-98% yield.

키워드

2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl-5-(2'-methylthio) ethyl ester methyl iodide salt hydrolyze 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropy ridine-3,5-dicarboxylic acid mono methyl ester 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicaboxylic acid 3-mono isopropyl ester