Phenylephrine에 의한 수축에 대한 Sodium Nitroprusside의 혈관수축 증대효과

• 영문명: The Potentiation Effect of Sodium Nitroprusside on the Contraction Induced by Phenylephrine in Rat Aortic Rings
• 발행기관: 대한약학회
• 저자명: 제현동(Hyun Dong Je)
• 간행물 정보: 『약학회지』제50권 제3호 (2006년), 208~213쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.06.30

영문 초록

Rat aortic ring preparations were mounted in organ baths, exposed to sodium cyanide (0.01~1.0mM) for 10min, and then subjected to contractile agents or relaxants such as acetylcholine, sodium nitroprusside and isoproterenol. Presence of low concentration of sodium cyanide did not affect the contractile response to KCl or phenylephrine in the aortic rings with intact endothelium or endothelium denuded. Sodium nitroprusside but not acetylcholine or isoproterenol augmented phenylephrine-induced intact or denuded vascular contraction in the presence of low concentration of sodium cyanide. In conclusion, this study provides the evidence concerning the potentiating effect of sodium nitroprusside on the contraction induced by phenylephrine in rat aortic rings regardless of endothelial function.

키워드

sodium nitroprusside phenylephrine KCl sodium cyanide