사이토카인 생산에 미치는 생지황메탄올추출물의 효과

• 영문명: Effect of Fresh Rehmanniae Radix Methanol Extracts on the Production of Cytokines
• 발행기관: 대한약학회
• 저자명: 채병숙(Byeong Suk Chae) 신태용(Tae Yong Shin)
• 간행물 정보: 『약학회지』제50권 제3호 (2006년), 184~190쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.06.30

영문 초록

We investigated the effect of fresh Rehmanniae radix methanol extracts (RGMeOH) in the in vitro production of cytokines by splenocytes and perigoneal macrophages isolated from C57BL/6 mice. Peritoneal macrophages and sple- nocytes were incubated with various concentrations of RGMeOH in the presence of 10μg/ml of lipopolysaccharide (LPS) or 1μg/ml of concanavalin A (Con A) for cytokine assay. These results showed that RGMeOH remarkably attenuated LPS-increased production of TNF-α but IL-6 by peritoneal macrophages and enhanced LPS-stimulated production of IL-10 in a dose-dependent manner. RGMeOH significantly augmented the LPS-or Con A-stimulated production of IL-2 and IFN-y by splenocytes. These findings suggest that RGMeOH may attenuate inflammatory responses through down-regulation of TNF-α and up-regulation of IL-10, and RGMeOH may up-regulate cell-mediated immune responses through increase in IL-2 and IFN-y production.

키워드

Rehmanniae radix TNF-α IL-6 IL-10 IL-2 IFN-y