참당귀(Angelica gigas) 뿌리 추출물로부터 (+)-Decursinol의 대량 제조 방법

• 영문명: A Mass Preparation Method of (+)-Decursinol from the Roots of Angelica gigas
• 발행기관: 대한약학회
• 저자명: 이지현(Jee-Hyun Lee) 최용석(Yong-Seok Choi) 김주환(Joo-Hwan Kim) 정혜광(Hye-Gwang Jeong) 김동희(Dong-Hee Kim) 윤미영(Mi-Yong Yun) 김진숙(Jin-Sook Kim) 이상한(Sang-Han Lee) 조수현(Soo-Hyun Cho) 신귀남(Gui-Nam Chen) 김의검(Eui-Geom Kim) 김문일(Wen-Yi Jin) 송규용(Gyu-Yong Song)
• 간행물 정보: 『약학회지』제50권 제3호 (2006년), 172~176쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.06.30

영문 초록

The purpose of this study is to develop a mass preparation method of (+)-decursinol from Angelica gigas roots. Recently, it has been shown that (+)-decursin, (+)-decursinol angelate and its analogues, isolated from Angelica gigas root, exhibit various biological activities such as antitumor, antibacterial and neuroprotective activities. The contents of these compounds, ester form of (+)-decursinol, is very high in the Angelica gigas roots, whereas the content of (+)-decursinol itself is very low. Therefore, (+)-decursinol which can be used as starting material to synthesize various its analogues was easily prepared from decursin analogues in the Angelica gigas roots. In order to achieve such aim, the Ether-Fr, of the ethanol extract of Angelica gigas root was hydrolysed with various alkalis and solvents. As a result, the order of (+)-decursinol preparation was 1) NaOH, KOH, 2) K2CO3, and 3) NaHCO3 as alkali. Also, the yield of (+)-decursinol was higher in diethyl ether than any other solvent conditions. From 1kg of dried Angelica gigas roots, we could obtain 27.4g of (+)-decursinol as a pure white solid.

키워드

Angelica gigas (+)-decursinol (+)-decursin alkali hydrolysis