Bl6 Me1anoma 세포에서 다시마 열수추출물이 멜라닌 생성에 미치는 영향

• 영문명: Effect of Hot-water Extracts from Laminaria japonicus on Melanin Production in B16 Melanoma Cells
• 발행기관: 대한약학회
• 저자명: 박연종(Yoon Jong Park) 윤미연(Mi Yun Yoon) 임혜원(Hye Won Lim) 이지윤(Ji Yun Lee) 김창종(Chang Jong Kim) 심상수(Sang Soo Sim)
• 간행물 정보: 『약학회지』제48권 제6호 (2004년), 374~378쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2004.12.31

영문 초록

To investigate the whitening activity of Laminaria japonicus, we measured the effect of hot-water extracts on melanin production in B16 melanoma cells. Melanocyte stimulating hormone (MSH, 1 ㎛)-stimulated melanin production in B16 melanoma cells was significantly inhibited by fucoidan and hot-water extracts, but not by alginate. The purified tyrosinase activity was not affected by hot-water extracts, alginate and fucoidan. However, tyrosinase expression was significantly inhibited by fucoidan and hot-water extract in Western blot. These results suggest that inhibitory mechanism of hot-water extracts on melanin production may be due to the inhibition of tyrosinase expression but not to direct inhibition of tyrosinase, such an effect of which may be dependent on fucoidan.

키워드

Laminaria japonicus alginate fucoidan melanin tyrosinase