임상분리 호흡기 감염증 원인 균주에서의 Macrolide계 항생물질의 내성

• 영문명: The Prevalence of Macrolide Antibiotics Resistance in the Clinical Isolates of Common Respiratory Pathogens
• 발행기관: 대한약학회
• 저자명: 윤은정(Eun-Jeong Yoon) 하장범(Jang-Bum Ha) 최응칠(Eung-Chil Choi) 심미자(Mi-Ja Shim)
• 간행물 정보: 『약학회지』제48권 제6호 (2004년), 364~368쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2004.12.31

영문 초록

The prevalence of resistance to a range of macrolides was determined for clinical isolates of common respiratory pathogens using NCCLS testing methods and interpretative criteria.71.4% of Streptococcus pneumoniae, 62.3% of Staphylococcus aureus, 50.8% of coagulase-negative staphylococci and 4.4% of Strpetococcus pyogenes were erythromycin resistant. Also, the rates of resistance to other macrolides and clindamycin in these clinical isolates were as high as to eryth -romycin. Almost all of the macrolide-resistant isolates were positive for erm of the methylase gene, or mef of the efflux gene.

키워드

macrolide resistance S. aureus CNS S. pyogenes S. pneumoniaef H. influenzae M. catarrhalis