흰쥐의 염증반응에 대한 CW-501027과 CW-501029의 억제효과

• 영문명: The Inhibitory Effect of CW-501027 and CW-501029 on the Anti-inflammatory Action in Rats
• 발행기관: 대한약학회
• 저자명: 정지훈(Ji Hoon Jung) 심재호(Jae Ho Sim) 양성준(Sung Jun Yang) 민영실(Young Sil Min) 송현주(Hyun Ju Song) 우재광(Jae Gwang Woo) 김용성(Yong Sung Kim) 조영래(Young Rae Cho) 손의동(Uy Dong Sohn)
• 간행물 정보: 『약학회지』제48권 제6호 (2004년), 317~322쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2004.12.31

영문 초록

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their ability to induce gastrointestinal injury. It has been shown that nitric oxide (NO), similar to prostaglandins (PGs), appears to play an important role in gastric mucosal defence. We hypothesized that NSAIDs contained NO group would be less acutely toxic to the gastric mucosa, but would not interfere with their ability to suppress inflammatory process in rats. We have compared the ulcerogenic and anti-inflammatory effect of CW-501029 (NO-NSAIDs), CW-501027 (NSAIDs) and indomethacin. Both did not change mean blood pressure and heart rates, indicating that they had no side effect on cardiovascular system. We found that CW-501029 increased nitrite/nitrate levels without changing of blood pressure and heart rates. We suggest that it may help gastric mucosal blood flow, the which helps reducing the discomfort in astrointestinal system. Carrageenan-induced PGE2 increase was reduced in a similar tendency when compared CW-501027 or CW-501027 with control in back exudate of rats, but CW-501029 less reduced PGE2 than CW-502027 or indomethacin in gastric tissues. CW-501027 or CW-501029 reduced platelet aggregation. From these results we suggest that CW-501029 may improve the side effect by reduction of short-term gastric injury and less inhibition of PGs synthesis.

키워드

anti-inflammatory effect CW-501029 NO NSAIDs