에토석시미드의 HPLC 분석법 및 한국인에서의 약동학적 특징

• 영문명: HPLC Determination and Pharmacokinetic Profile of Ethosuximide in Korean Subjects
• 발행기관: 대한약학회
• 저자명: 배정우(Jung-Woo Bae) 김지홍(Ji-Hong Kim) 양상인(Sang-In Yang) 김현경(Hyun-Kyung Kim) 장춘곤(Choon-Gon Jang) 한혜원(Hye-Won Han) 박영서(Young-Seo Park) 손의동(Uy-Dong Sohn) 이석용(Seok-Yong Lee)
• 간행물 정보: 『약학회지』제47권 제6호 (2003년), 444~449쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.12.31

영문 초록

Ethosuximide is an oral anticonvulsantic agent used in the first choice anti-absence seizure drug. The purpose of this study was to assess the pharmacokinetic profile of the ethosuximide in healthy Korean volunteers and to develop the efficient assay method of ethosuximide in human plasma. The pharmacokinetics of ethosuximide administered orally was evaluated after a dose of 500 mg. Ethosuximide was assayed from plasma by a specific HPLC method reading absorbance at 195 nm. AUC was 1222±160 μg/ml·hr, Cmax 14.21±1.74 μg/ml, Tmax 1.06±0.62 hr and half-life 77.83±12.46 hr. The half-life in Korean was longer than, in Caucasian (53~56 hr).

키워드

ethosuximide pharmacokinetics HPLC.