B16 Melanoma 세포에서 Phenylpropanoid 화합물이 Melanin 생성에 미치는 영향

• 영문명: Effects of Phenylpropanoid Compounds on Melanin Production in B16 Melanoma Cells
• 발행기관: 대한약학회
• 저자명: 박영미(Young Mi Park) 윤미연(Mi Yun Yoon) 김경원(Kyoung Won Kim) 조남영(Nam Young Cho) 임혜원(Hye Won Lim) 이지윤(Ji Yun Lee) 이진희(Jin Hee Lee) 김연정(Youn Joung Kim) 김창종(Chang Jong Kim) 심상수(Sang Soo Sim)
• 간행물 정보: 『약학회지』제47권 제6호 (2003년), 398~403쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.12.31

영문 초록

To investigate the relationship between structure and bioological activity of phenylpropanoids, we measured effects of phenylpropanoids on anti-oxidant activity. Although phenylpropanoids did not inhibit purified-tyrosinase activity, they significantly inhibited tyrosinase activity and melanin production in MSH-stimulated B16 melanoma cells. However, phenylpropanoids did not affect tyrosinase expression in MSH-stimulated B16 melanoma cells, which suggest that inhibition of MSH-induced melanin production was due to tyrosinase inhibition mediated via other signal pathways but not expression of tyrosinase. Phenylpropanoids also significantly inhibited both hyaluronidase and elastase activity, suggesting that phenylpropanoids plays an important role in anti-oxidant and whitening activity.

키워드

phenylpropanoids melanin hyaluronidase elastase tyrosinase.