금속 니트로소 R염 착물을 이용한 염기성 의약품 선택성 전극의 특성

• 영문명: Potentiometric Characteristics of Nitroso-R-Salt-Metal Complex Based Basic Drug Selective Electrodes
• 발행기관: 대한약학회
• 저자명: 이미나(Mi-Na Lee) 안문규(Moon-Kyu Ahn)
• 간행물 정보: 『약학회지』제47권 제6호 (2003년), 356~360쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.12.31

영문 초록

Nitroso-2-naphthol-3,6-disulfonic acid, disodium salt (NRS) was used as an organic ligand to prepare basic drug-selective polymeric membrane electrode. The sensing membrane of the electrode consited of basic drug-metal(II)-NRS as an ion-exchanger site in a poly(vinyl chloride) matrix plasticized with 2-nitrophenyl octyl ether (NPOE). The metal ions used were Fe2+, Co2+, Ni2+ and Cu2+. The eletrodes exhibited fast and wide linear response in the basic drug concentration of 10-5~10-3 mol/l with a response slope of 50~60 mV/decade in a buffer solution of pH 4~8. The electrodes exhibited good selectivity for many basic compounds.

키워드

NRS complex organic ligand basic drug.