Nalbuphie의 병용투여에 의한 morphine의 내성 및 의존성 헝성 저하효과

• 영문명: The Development of T31erance to and Dependence on Morphine are Reduced by Co-administration of Nalbuphine in Rat
• 발행기관: 대한약학회
• 저자명: 정면우(Myeon Won Chung) 임화경(Hwa Kyung Lim) 전용준(Yong Joon Jeon) 김혜정(Hye Jung Kim) 박인숙(In Sook Park) 오우용(Woo Yong Oh) 왕소영(So Young Wang) 박윤주(Yoonju Park) 강주희(Ju Hee Kang) 김동섭(Dong Sup Kim) 김주일(Joo Il Kim) 오세관(Seik Wan Oh) 최기환(Ki Hwan Choi)
• 간행물 정보: 『약학회지』제46권 제4호 (2002년), 276~282쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.08.31

영문 초록

Morphine has been used widely on the treatment of many types of chronic pain. However the development of tolerance to morphine by repeat application is a major problem in pain therapy: The purpose of the present study was to investigate whether combined administration of nalbuphine with morphine affects the development of tolerance to and dependence on morphine. We hypothesize that the use of nalbuphine, k-agonist may prove to be useful adjunct therapy to prevent morphine-induced undesirable effects in the management of some forms of chronic pain. Morphine (10 mg/kg) was injected to rats intraperitoneally for 5 days. The variable dose of nalbuphine (0.1,1.0 and 5.0 mg/kg) was administered (I.p.) in combination with morphine injection. The development of tolerance to morphine was assessed by measuring the antinociceptive effect with the Randall-Selitto apparatus. The development of dependence on morphine was determined by the scoring the precipitated withdrawal signs for 20 min after injection of naloxone (10 mg/kg,I.p.). Nalbuphine did not attenuate antinociceptive effect of mofhine in rats. Interesting1y; combined administration of morphine with nalbuphine (100:1) sign- nifcantly attenuated the development of morphine tolerance and dependence. These results suggest that the co-admin-istration of nalbuphine with morphine in chronic morphine treatment can be one of therapies to reduce the development of dependence on morphine.

키워드

Morphine nalbuphine tolerance dependence.